I don't watch Anime a lot, and I'm not particularly into Anime, but this show blew my mind in so many ways. It is, in my opinion, perfection.
The animation, the characters, the bizarre editing style and humor (which is genius, because it melds slice of life with super expressive over-exaggerated action anime) the music (holy smokes, the music is fantastic) and the story / skits; everything worked great.
I love the 3 main characters, their chemistry is excellent, and they are very funny when they are together. The side characters, Nano, the Professor, and Mr. Sakamoto is one of the most fascinating character dynamics I've ever seen, I love every second of their story-line, it is a super unique trio of characters.
This is a super under-rated show. Why? Because not many people know about it, and when it was released, it didn't find much success. Some of the clips get millions of views, and I happen to learn about it from a YouTube video about it, but it needs more love, and more watch time. It is very sad to know that a second season won't come to light because of how poorly it did financially.
I hope the animators and the people who worked on this show know that there is a loving fan-base that adores and supports their show, and I hope they do great things with their talents. Please watch this show!