- Seth MacFarlane: By the way, Donald, it's pronounced "huge," not "eyuge". Also, it's pronounced "I am fucking delusional," not "I am running for President."
- Snoop Dogg: Now he's talking about running for President. Why not? It wouldn't be the first time he kicked a black family out of their house.
- Anthony Jeselnik: Look at this Dais. You've got a pimp, a murderer, a drug dealer, a pornographer... and then eight white people.
- Marlee Matlin: [Signing] I guess I'm the perfect choice for this roast because like The Situation, I, too, have never heard the sound of laughter.
- Gilbert Gottfried: I've heard word that Donald Trump has done so much damage to the New York Skyline, that instead of calling him the Donald, they should call him the 20th hijacker.
- Mike 'The Situation' Sorrentino: [the Situation is constantly getting booed for every joke he makes] Jeff, you and I have a lot in common. We're both from Jersey and tonight's my first night doing comedy.
- Jeffrey Ross: [chuckles and gets up] It's also your last night just so you know!
- Seth MacFarlane: [after The Situation's abysmal comedy routine] Alright, we wanna thank the Pope for that marvelous speech.
- Whitney Cummings: Larry King you have had a heart attack, bypass surgery, you have heart disease, and you recently got stents placed in your coronary artery; take a hint, God wants you to die.
- Anthony Jeselnik: Donald, I'm not sure if you're even aware of this, but the only difference between you and Michael Douglas from the movie, Wall Street, is that no one's going to be sad when you get cancer.
- Seth MacFarlane: [about Mike Sorrentino] A lot of people laughed at him for hooking up with his co-star, Snooki, but Italians are known for grinding organs with monkeys.
- Larry King: Snoop told me before the break that once he took a DNA test and found out he is only 71% black. Is that true? Unless my math is wrong, if you're 71% black, you're 29% not guilty.
- Anthony Jeselnik: Jeff Ross has been roasting people since Whitney Cummings was nothing but a glint in the eye of the man who raped her mother.
- Gilbert Gottfried: [Speaking for Marlee] Thank you, Donald Trump. You're the best. This has been a thrill for me. It's not often that you get a boss that can laugh at himself.
- [pause]
- Marlee Matlin: [Speaking] Now, please stop staring at my tits.
- Larry King: Donald Trump is not only one of my oldest and dearest friends, he is an American success story. When he graduated college, he put his shoulder to the wheel, nose to the grindstone... borrowed $6 million from his father, and started a career. Donald Trump, without a doubt, you're a New York landmark. Which means it will only be a matter of time before you bulldoze yourself and put up some gaudy, tacky monstrosity, and put your name on it.
- Anthony Jeselnik: [to The Situation] Mike Sorrentino... great job, by the way. Mike, you're doing really well right now. You've got a cologne, a workout video, a vodka. You've got your name on everything... except a High School Diploma. And Sitch, I don't wanna tell you how to live your life, man, but if you've spent half of your time reading books as much as you do chasing skanks, you probably wouldn't have AIDS.
- Whitney Cummings: [to the Don] You got Melania a huge 12 karats diamond engagement ring. You should not have gotten her a diamond- now she knows what hard is supposed to feel like.
- Whitney Cummings: [to the Don] On your show, The Apprentice, you've had Nene Leakes from The Real Housewives, Brande Roderick and Lisa Rinna- you've given more uneducated whores on-camera jobs than Fox News.
- Marlee Matlin: [Signing] Not many people know this, but I replaced Lisa on The L-Word. Apparently, the only way she would eat pussy is if there were french fries in it.
- Anthony Jeselnik: Larry King's been married eight times. Eight times! Jesus, man. You've got 99 problems and bitches are all of them!
- Jeffrey Ross: [as The Situation is getting boo'd, Jeff Ross comes up to help him out] You know 'The Situation'?
- [lifts up his shirt to reveal his gut]
- Mike 'The Situation' Sorrentino: That's definitely a situation right there.
- Jeffrey Ross: They call me 'The Saturation'!
- Whitney Cummings: [to the Don] You recently said that you wanted to run for president- that is such a publicity stunt. If I wanted to support a greedy whore who's pretending to run for president just to get on TV, I'd vote for Sarah Palin.
- Larry King: Marlee, always a pleasure. What on earth are you doing here? You won the Academy Award for Children Of A Lesser God, and then nothing for years. I don't understand it. You were *so* convincing playing a deaf woman.
- Mike 'The Situation' Sorrentino: [to Donald] I've seen pictures of your house. Everything in your house is gold. Who the fuck decorated your house, Flava-Flav's dentist?