First episode directed by Kevin McKidd (Owen Hunt)
While in surgery, Lexie makes a reference to Silence of the Lambs. Brooke Smith, who played Dr. Erica Hahn in seasons 2-5 was in Silence of the Lambs.
Every episode of the show is named after a famous song. "Don't Deceive Me (Please Don't Go)" is the title of a song originally performed by James Brown.