Parker receives the book "Misery Unchained", a first edition signed by the author "before that lady chopped his foot off". This refers to the Stephen King book 'Misery'.
In the basement, Duke trips over a red tricycle in a hallway. Since they'll all in a creepy hotel, it could be a nod the Stephen King's: The Shining
The island this episode takes place on is called Carpenter's Knot, owned by Vaughn Carpenter. This could be a nod to film director John Carpenter who directed "The Thing" (1982) which share a similar life form who kills and imitates its victims.
Julia refers to the Chameleon as "The Thingamabob" to which Audrey replies "I am not the Thingamabob!" This may be a reference to the John Carpenter film "The Thing" (1982) starring Kurt Russell. The film revolves around a group of researchers trapped in a remote facility with an parasitic life form that can assimilate and imitate people. The plots of that film and this episode share this similarity.
Shapeshifters were a common occurrence on Supernatural (2005), which aired on the CW network both before and after this series. Both were filmed in Canada, albeit on opposite coasts.