Myka graduated in 2000, making her age 27 or 28 as of this ep.
Leena's picture of RLS is an actual photograph with the background faked to show the bookend artifacts.
Joanne Kelly (according to her bio) was born in 1978 which means she would have graduated from High School (at 18-19) in 1996. But the Marquis in front of the hotel says class of 2000. So, she would have graduated at the age of 21 or 22.