This is the lowest rated season premiere / opening episode (as of June 2018) and is the first episode after Kripke's original 5-year run.
When Dean is explaining to Sid why he has a gun, he mentions that opossums carry rabies. In fact, rabies is extremely rare in opossums.
After Dean leaves the bar with his Suburbia buddy and hears the woman scream, he grabs a flashlight from his work truck and goes to investigate. The posters on the door he opens are for a DJ called "DJ Sam."
The yellow truck in the beginning of the episode was the same exact one Henry Spencer drove in Psych (2006).