Both Chyler Leigh (Dr. Lexie Grey) and episode guest star Courtney Ford (Jill Meyer, the sister of Teddy and Arizona's patient) are part of the Arrowverse, Leigh as Dr. Alex Danvers (mostly on Supergirl) and Ford as Nora Darkh (mostly on DCs Legends of Tomorrow).
Every episode of the show is named after a famous song. "Perfect Little Accident" is the title of a song by Saturday Morning Soundtrack.
Chelcie Ross (who plays Harper Avery, Jackson's paternal grandfather) is only 39 years older Jesse Williams (the actor who plays his grandson), and 9 years older than Debbie Allen (the actress who plays Catherine Avery, and who would have been Harper Avery's daughter-in-law).
Chelcie Ross (Harper Avery) and Tess Harper (Mrs. Nelson) previously started together in Christy (1994).