According to the commentary, it was Hugh Laurie's idea for House to be playing George Michael's "Faith" at the beginning of the episode.
House is watching TV when Wilson arrives, and you hear the line "bushido of the heel," a reference to the fictitious comic book/sci-fi TV series "Stiletto: Warrior Queen of Space" mentioned three episodes earlier in "Known Unknowns."
Once Wilson arrives home at an odd hour, House quips, "Late night with the Pigeon sisters?" This is a reference to Oscar and Felix's neighbors on The Odd Couple (1968) in which two middle aged men also live together - a concept explored further in the following episode.
When Wilson correctly diagnoses depression in his elderly African American patient due to not talking about his grandchildren as usual, it is a catch House would never have made because he tries to avoid talking to his patients at all costs.
Joshua Malina and Lisa Edelstein also starred in The West Wing, though never at the same time.