Ralph Waite as Irving Waller says, "There's just gotta be more to life than eating pudding and watching CSI." Ralph Waite played Sheriff Montgomery in an episode of CSI in 2008.
Jocko Sims, who played cancer patient Randy Helsby in this episode, went on to play a surgeon on New Amsterdam. Owen tells Izzie that she can't be both a doctor and a patient (because of her own cancer); a major plot point on New Amsterdam, at least in the first season, is Sims's character's boss having cancer and continuing to run the hospital and treat patients while undergoing his own treatment.
Jocko Sims and Eric Dane work together on The Last Ship