Through the Make-A-Wish Foundation, 13-year-old Connor McGrath, a terminally ill fan from Edmonton, requested to attend the special event for Deadpool (2016) in January, which turned out to be one of the two special screenings in New York and Los Angeles for the fans. He couldn't make it, due to the severity of his illness. Ryan Reynolds heard his story, traveled to Edmonton, and surprised him with a private special screening of the film. Reynolds said the boy was the first person ever to see the film. They kept in touch until Connor's passing a few months later. Reynolds paid tribute to him on his social media pages.
During a talk at Google, Ryan Reynolds revealed that the taxi driver character "Dopinder" was named after "a really cool guy" he knew in elementary school who died when hit by lightning. The character was meant to be a tribute to him.
When 20th Century Fox refused to pay the writers of the film, Rhett Reese and Paul Wernick, for on set input, Ryan Reynolds paid out of his own pocket for them to be on set to look over the film. Reese stated, "We were on set every day. Interestingly, Ryan wanted us there, we were on the project for six years. It was really a core creative team of us, Ryan, and director Tim Miller. Fox, interestingly, wouldn't pay for us to be on set. Ryan Reynolds paid out of his own money, out of his own pocket."
Ryan Reynolds has said that Deadpool will be the last comic book character he will ever portray. However, he doesn't object to future Deadpool sequels and/or cameos.
Rob Liefeld: (at around 17 mins) the creator of Deadpool, a customer at the bar when Wade addresses two people: "Buck... Liefeld"