Thanks to the big success of the show, the tourism on the village where it's filmed has increased notably.
For the firsts two seasons, Alex O'Dogherty and Esperanza Pedreño worked simultaneously on Camera café (2005), Fibrilando (2009) and this show.
Natalia Verbeke's absence in Season 3 was due to the shooting of The Women on the 6th Floor (2010) in France.
There is not exists a town named San Martín del Sella (where the series set). Actually it was filmed mainly in the little coastal town of Lastres (and surroundings), belonging to the municipality of Colunga (Principality of Asturias, north-west to Spain). Several extras of the series were real-life Lastres' villagers.
Doctor Mateo is based up the hit UK TV Series Doctor Martin which was itself a spin-off of Portman's hugely successful movie Saving Grace.