Thanks to the efforts of the covert organisation, Furry Animal Rivalry Termination, the fragile peace between cats and dogs, known as the Great Truce, has been seamlessly maintained for the past decade. Without a doubt, after the events of
Cats & Dogs: The Revenge of Kitty Galore (2010), this has been the most peaceful and uneventful period in the history of both species; however, war is brewing over. This time, it seems that an ambitious megalomaniac, and his tech-savvy accomplice, have managed to hack into the agency's online observation system, bent on inflaming old rivalries. Now, it is up to the pair of untried undercover agents, Gwen, the orange tabby cat, and Roger, the sheepdog, to avert a sinister conspiracy of global proportions, along with a handful of brave four-legged spies. Can they restore peace before it is too late?
—Nick Riganas