Anthony Edwards agreed to return for this episode on the condition that his salary would be donated to his favorite charity. Producers agreed, and donated his salary, and matched it with their own money. Steven Spielberg, the Executive Producer, also heard about this agreement. He matched the contribution as well.
This episode opens with Eriq la Salle mentioning the loss of writer/creator Michael Crichton the week prior to the original airing of the episode. It's followed by a photo with "In Memory of Michael Crichton (1942-2008)."
Final appearance of Anthony Edwards (Dr. Mark Greene) and Paul McCrane (Dr. Robert Romano) in the series.
Courtney B Vance and Angela Basset play husband and wife, they are also married in real life.
In the 15th and final season, the show wanted to bring back every key character from the show's past for at least one cameo appearance each. This presented a quandary regarding Anthony Edwards and Paul McCrane, whose characters had died in Seasons 8 and 10. So the producers devised a flashback structure for an episode which took place in 2002 and (briefly) brought Dr. Mark Greene and Dr. Robert Romano back to the series.