Robert Downey Jr. reprises his role as Tony Stark for this game. However, a different actor, Stephen Stanton, voiced Iron Man. The reason behind why two different actors portrayed the same character (his superhero persona and his alter ego) is unknown.
Tony Stark mentions that he has a date with Natasha Romanoff, despite the fact that he did not meet her until Iron Man 2 (2010).
This game contains several plot points that contradict the established canon of the Marvel Cinematic Universe and it is thus considered non-canon.
During his battle against Titanium Man at Stark Industries, Titanium says "Who do you think you are?", Iron Man replies "A genius, billionaire, playboy, philanthropist? You tell me". This phrase was later popularized in The Avengers (2012).
In the Neffaria Manor mission, Iron Man tells Whitney Frost that if she wants to play hide-and-seek, he can borrow her a mask. In the comics, Whitney Frost is also known as Madame Masque, and she wears a golden mask to cover a scar over his face.