The on-screen credits list Yannick Bisson's character as "Inspector William Murdoch", even though his actual position is "Detective William Murdoch".
As the doctor examines Wendell Merrick's body on the floor, his finger moves, even though he's supposed to be dead.
Murdoch mentions the cities of London, Windsor and Cambridge: Cambridge Ontario was not a city until 1973 when the town's of Galt, Hespler and Preston were amalgamated.