Brackenreid and others refer to Doyle killing off his creation Sherlock Holmes and the author explains why. In Doyle's story. "The Final Problem" both Holmes and Professor Moriarity both fall over Switzerlan's Reichenbach Falls to their death. That story, set in 1891 and published in 1893, was written so as to allow Doyle to go back to his first love, historical novels, but, in fact, popular pressure forced the writer to resurrect the character.
Presummably Doyle will adapt Inspector Brackenreid's story of the "Hell Hound of the Highlands" to "The Hound of the Baskervilles." He even suggests that the setting should be changed to the Moors. This episode takes place in 1895 and Doyle did not publish "The Hound" until 1902.
Doyle mentions to Dr. Ogden that he has performed many autopsies. In fact, the real Doyle was an ophthalmologist. He didn't have a successful practice and turned to writing while waiting for patients.
On their way to the Toronto Paranormal Society at night, Det. Murdoch tells Arthur Conan Doyle that his late fiancée, Liza, died of consumption over a year ago.
At the very start, Murdoch calls out to Doyle, "Mr. Doyle...Sir Arthur Conan Doyle". Unfortunately the show is set in the late 1880's whereas Doyle was not knighted until 1902. Murdoch even with his prescience ability, would not have greeted him that way.