This was the last WWE event to be held in front of a live crowd, as following the event, WWE would move their shows to the WWE Performance Center in Orlando, Florida, due to the COVID-19 pandemic; live touring for every events were resumed starting at Money in the Bank in July 2021.
This was the first year that the PPV was held in March instead of the usual February .
For the first time in event history. No match was held for the main titles (Universal or WWE Heavyweight Title).
Shayna Baszler became the first superstar of either gender to single-handedly eliminate all other participants in the Elimination Chamber match, and the first to eliminate five participants in a single EC match since Braun Strowman in the 2018 men's EC match (which had seven participants and of which he eventually lost to Roman Reigns).
The women's Elimination Chamber match was the shortest EC match in the history of the PPV of the same name, and the shortest since the 2003 match at SummerSlam.