In the teaser, a man dressed as an astronaut is found dead. Before the cut to the title sequence, Mac Taylor (Gary Sinise) intones, "Houston, we have a problem." This is the famous misquote ("Houston, we've had a problem") spoken by CSM pilot Jack Swigert (Kevin Bacon) and mission commander Jim Lovell (Tom Hanks) in Ron Howard's Apollo 13 (1995). Sinise played grounded CSM pilot Ken Mattingly in that film.
Aaron Behr (Vinnie Parson) appears in the CSI: Miami (2002) episode Wolfe in Sheep's Clothing (2009) (#7.20) in a different role.
Christopher Bello (John Szabo) appears in the CSI: Miami (2002) episode Caged (2011) (#9.19) in a different role.