When Shawn is running around the museum and Gus is tracking him, the woman that Shawn tries to sneak out behind (when Gus says "Leave that poor woman alone") is played by Dulé Hill's mother.
When Gus is telling Shawn that watching him sneak through the museum is like "watching Entrapment, but instead of watching Catherine Zeta-Jones, they have some guy with pancake butt," the man walking past Shawn is writer/executive producer ans show creato, Steve Franks.
Toward the end of the episode "65 Million Years Off," Shawn says he is going to name the dinosaur he uncovers "Zippy," after he unearths it. It is revealed in this episode that the dinosaur is indeed named Zippy.
First episode to show any depiction of Shawn's mother
"Zippy", the name given to the dinosaur in the episode, was actually the name of Steve Franks' sister's cat who lived for 23 years.