This episode has Chuck give a good speech at his father's wedding. He says: 'In the face of true love you don't just give up even if the object of your affection is begging you to.' I know that I have tried chasing after a true love in the past who has never responded to my letters. This is discouraging, and I've ended up giving up. However, I have consistently followed my dream and not given up on my childhood ambition. Maybe I'm more in love with my dream than I have been with any person.
After the speech, Blair tells Chuck he doesn't belong with anyone, even though he went on to say that 'one day I hope I'll be lucky enough to find someone' who won't give up on me. I know that a lot of people have given up on me, but that's what makes Serena so attractive. She doesn't give up on Blair, and even tells her that she is willing to fight alongside of her to make the relationship work.