The first Marvel movie based on a character that did not have their own self-titled comic series.
Unusually for a Marvel Comics-related movie, there are no post-credit scenes.
Sydney Sweeney said of this film, "To me, that film was a building block, it's what allowed me to build a relationship with Sony. Without doing Madame Web I wouldn't have a relationship with the decision-makers over there. Everything in my career I do not just for that story, but strategic business decisions. Because I did that, I was able to sell Anyone But You (2023). I was able to get Barbarella."
First film to use the Columbia Pictures 100th anniversary opening logo to celebrate the studio's centennial anniversary.
Sony reportedly had plans for either Andrew Garfield or Tom Holland to appear as Spider-Man, but ultimately cut all references to Spider-Man from the final film.
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