- Malcolm Bright, a former FBI profiler, is the son of a serial killer and suspects that he himself might become a sociopath. He solves crimes for the NYPD as a form of absolution for his upbringing.
- The series centers on Malcolm Bright, whose father, Martin Whitly, is the infamous serial killer known as "The Surgeon". As a child, Malcolm was responsible for enabling the police to arrest his father, and has not seen his father in ten years after joining Quantico. A disgraced former FBI profile who now works for the NYPD, Malcolm is forced to confront his father after a copycat serial killer uses Whitly's methods of killing. He finds himself drawn back into constant contact with his father as he must both use Whitly's insights to help the police solve particularly horrible crimes and battle his own inner demons. Tom Payne as Malcolm Bright (formerly known as Malcolm Whitly), a disgraced former FBI profile, who now works for the NYPD. He possesses the unique ability to view crimes from the perspective of the killer, allowing him to pick up on things that other cops might miss. However, this gift also haunts him, causing him to live in a perpetual state of fear that he will one day succumb to the same sociopath tendencies as his father. Kasjan Wilson as Young Malcom Bright Lou Diamond Phillips as Gil Arroyo, a lieutenant with Major Crimes in the NYPD. He was the arresting officer of Martin Whitly and, since then, has acted as a surrogate father to his son, Malcolm; Gil hires Malcolm as his new consultant after the latter is fired from the FBI. Halston Sage as Ainsley Whitly, Malcolm's ambitious younger sister; a TV news reporter. Aurora Perrineau as Det. Dani Powell, an officer under Arroyo's command who is sympathetic to Malcolm's personal issues. Frank Harts as Det. JT Tarmel, an officer under Arroyo's command. Keiko Agena as Dr. Edrisa Tanaka, an NYPD medical examiner with an interest in Malcolm. Bellamy Young as Jessica Whitly, Malcolm's mother and a successful businesswoman from an old money high society family who suffers from alcoholism, as a result of her drinking to cope with her husband's crimes. Michael Sheen as Dr. Martin Whitly, Malcolm's father who is currently incarcerated in an asylum after committing twenty-three murders as "The Surgeon". Catherine Zeta-Jones as Dr. Vivian Capshaw (season 2) a resident medical doctor at the Claremont Psychiatric Hospital
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