Chris Williams, who plays Wilhelldiva Hater (the drag queen parody of Wilhelmina Slater), is Vanessa Williams' brother.
On Betty's nightstand sits a copy of the book The Sisterhood of the Traveling Pants. America Ferrera plays Carmen in the film version of the book.
Salma Hayek enjoyed being on set so much that she took advantage of her producer role to get the part of Sofia Reyes.
There is always a new decoration decorating the tunnel of Mode Magazine's halls. In the Pilot episode there is nothing on the shelves, but in the last episode there are, what looks like, papermache dolls of characters from the show, including (and best) a doll of Betty Suarez in her iconic poncho.
Mark's name in "Fake Plastic Snow" is Mark Saint-James, but in "Don't Ask Don't Tell," his name is Mark Weiner. (From a deleted scene from "Don't Ask Don't Tell," Betty asks Marc: "Your real name is Weiner?" Marc answers: "I had to change it. A gay kid named Weiner? I wanted to beat myself up.")