The episode title refers to a line from the play "Hamlet" (by William Shakespeare), Act 2, Scene 2: "I am but mad north-north-west: when the wind is southerly I know a hawk from a handsaw."
In this episode, Jerry O'Connell, plays a character called Joe and he has a 'roach infestation in his apartment. Jerry O'Connell appeared in the movie "Joe's Apartment" (1996) where he played the title character whose apartment had cockroaches that talked, sang and danced.