This is the first appearance of newscaster Brian Pinhead. Pinhead (pronounced Pin-Aid) has a large body and small head, which is a disorder called microcephaly. The slang term for this condition is "Pinhead" (pronounced Pin-Head). He replaces previous newscaster Sally Vacuum, who was taken away by giant whale Blow Hole in the previous episode.
Omnipotus is a thinly veiled parody of Marvel Comics' Galactus.
After this episode, the moon now also has a bite taken out of it
This episode is a parody of Silver Surfer from Marvel Comics, with Tick playing the Surfer and Omnipotus being the equivalent of Galactus.
After Omnipotus introduces himself, he eats a planet where a boy is seen watering a plant. This is a reference to "The Little Prince."