The title "Forever Ambergris" is a reference to the 1947 drama Forever Amber. The original comic story this episode was adapted from ambergris played an important part in the story's ending. Since this element was excised from the adaption, the title makes little sense.
The infection that Ike has is Miliaria.
In an interview on the podcast, "The Producer's Guide: Todd Garner & Hollywood's Elite", writer Scott Rosenberg stated that he and director Gary Fleder got a call from executive producer Richard Donner who told them that their episode was disgusting.
A mercenary wears a bandolier of shotgun shells, but none of the mercs has a shotgun.