Jonathan Frakes remarked: "Frame of Mind was really dark. It was a terrifying show and creepy to do. It was as big a show as any I've had to carry."
This is the second time that Riker has gotten into trouble and been trapped on an alien world during an undercover mission. The first was in the fourth season episode First Contact (1991).
This is the third time that Dr. Crusher has organized a play. She previously asked Geordi to sing some Gilbert & Sullivan for her in Disaster (1991), and held an audition in A Fistful of Datas (1992).
Susanna Thompson has played four characters in the Star Trek franchise, the Borg Queen in Dark Frontier (1999), Unimatrix Zero (2000) and Unimatrix Zero Part II (2000), Lenara Kahn in Rejoined (1995), Varel in The Next Phase (1992) and Jaya in Frame of Mind (1993).
David Selburg (Dr. Syrus) also played the historian Whalen in the first season episode The Big Goodbye (1988).