The producers requested a "Megan Gallagher type" for the role of Nurse Garland. Upon hearing about this, her agent contacted them and said that Gallagher might be able to do it herself. She was then offered the role.
The scene where all of the Humans observing the "Martians" behind the one-way mirror were smoking was a deliberate commentary on the use of tobacco in the 1940s. Initially, the studio was originally against having anybody at all smoking in the episode, but Ira Steven Behr pointed out that they couldn't do an homage to '50s B-movies without seeing the characters smoke.
This is the first episode where entire sentences of Ferengi language are heard.
Nog notes that Gabriel Bell from the Bell Riots looked a lot like Captain Sisko, referencing the events of Past Tense, Part I (1995)/Past Tense, Part II (1995).
This episode is a parody of 1950s science fiction films. All three of the major guest characters were named after actors who appeared in such films: (1) Dr. Jeff Carlson was named after Richard Carlson, who played Dr. Jeffrey Stewart in The Magnetic Monster (1953), John Putnam in It Came from Outer Space (1953) and David Reed in Creature from the Black Lagoon (1954), (2) Nurse Faith Garland was named after Beverly Garland, who played Vera in Swamp Women (1956) and Claire Anderson in It Conquered the World (1956) and (3) General Rex Denning was named after Richard Denning, who played Mark Williams in Creature from the Black Lagoon (1954) and Rick in Day the World Ended (1955).