The role of Senator Cretak was originally played by Megan Cole in "Image in the Sand" and "Shadows and Symbols". She was unavailable to reprise the role for this episode so the producers chose Adrienne Barbeau instead.
Although the storyline addresses the ongoing war with the Dominion, it is the last stand-alone story of the DS9 series. Every episode until the finale is one long story arc.
This is the first of only four times that Romulus is seen from orbit. The planet is not seen again until Star Trek Nemesis and later again in Star Trek: Enterprise's fourth season.
The USS Bellerophon seen here is an Intrepid class starship, the same kind as the USS Voyager. The producers used stock footage from Star Trek: Voyager (1995), as well as some of the same sets for the scenes aboard and off ship.
As they had done with the gray uniforms first seen in Star Trek: First Contact, the producers decided to hold back the white dress uniforms until after Insurrection was in movie theaters.