Luther tells Dr. Auschlander that his patient Cindy Cation has had 100 episodes of angina. Auschlander hopes that her heart will keep running for a long time to come. Cindy Cation is a reference to syndication while her angina episodes refer to the fact that this is the 100th episode of the series.
The title is a line from the series Rocky and His Friends. In addition, the Craig's Russian housekeeper named Natasha has moved to Frostbite Falls, MN, the setting of the classic cartoon show. When the Natasha character was first introduced, Craig asked her to say "moose & squirrel" another line from that series.
A moment with Bruce Greenwood and Stephen Furst telling Wil Wheaton that the room is for doctors and not kids features future stars of iconic science fiction franchises. Greenwood in Star Trek (2009), Wheaton in Star Trek: TNG, and Furst in Babylon 5 (1993).