Dr. Cox looks to "pitch a perfect game" by keeping all patients in the ICU alive until the end of his shift. He states that there are 27 patients. In baseball, a perfect game means that the pitcher retires all 27 batters he faces.
The MRI tech who pops up behind the window is played by Charles Papert, the camera operator on the show.
This is the first episode in which Dr. Cox calls Elliot "Barbie".
It is revealed that Dr. Cox likes his coffee with sugar and no cream.
The word 'malibu' is spelt out downwards on the whiteboard behind Dr Cox when he says "new game starts in 4 minutes".