The particularly fascinating guest cast offers among other things the only shared credit of two actors who would both later become best known for playing someone with the title of chief in an iconic TV series, Terry Becker (Chief Sharkey on Voyage to the Bottom of the Sea (1964)) and Edward Platt (the Chief of CONTROL on Get Smart (1965)).
The episode features as guest stars in their only shared credit two actors who would later star in spy-themed TV series: Edward Platt who would play the Chief of CONTROL on Get Smart (1965) and, barely noticeable as one of the gunmen told to leave the courtroom near the end, Patrick Macnee who would become best known as British agent John Steed on The Avengers (1961) and The New Avengers (1976) but would also replace series character Alexander Waverly in leading a different famous TV spy agency in the reboot TV movie The Return of the Man from U.N.C.L.E.: The Fifteen Years Later Affair (1983). Also appearing here is Robert Cornthwaite, who in three episodes of "Get Smart" as the spy device designer Windish, just like the Chief, is regularly frustrated by the ineptitude of Maxwell Smart.
Appearing here in his first of three "Rawhide" episodes, guest star Iron Eyes Cody had never played the role of Tonto in his career, but in an episode of Mister Ed (1961) some years later would play a character named "Chief Thundercloud," which was the name of the actor who originally played Tonto on screen in the serials The Lone Ranger (1938) and The Lone Ranger Rides Again (1939), with Cody having had a minor role in the first of those. The actor Chief Thundercloud died a few years before that "Mister Ed" episode and had worked many times with Cody, and both actors also worked numerous times with Jay Silverheels who would become the screen's most famous Tonto in the fifties TV series The Lone Ranger (1949) and two theatrical movies of the saga. Also appearing in this "Rawhide" episode is John Hart, who on the "Lone Ranger" series for just the third season would take over the title role from Clayton Moore due to a contract dispute, with Moore playing the role for the rest of the show's eight-year run (plus the two aforementioned "Lone Ranger" movies). Both Moore and Hart, by the way, in addition to having worked together a few times, had each worked with Thundercloud once and with Cody a few times, and of course co-starred with Silverheels on the show as well as in other unrelated movies. Hart and Silverheels would last play the Lone Ranger and Tonto together in a modern setting in the surreal all-star comedy bomb The Phynx (1970), with Hart later similarly playing himself as well as the Lone Ranger on the TV series Happy Days (1974) and The Greatest American Hero (1981). Hart would also have a cameo in the reboot movie The Legend of the Lone Ranger (1981), which ironically had barred Moore from wearing his Lone Ranger mask at certain public appearances during the theatrical run of the film.