The plot for this episode was taken from the pilot that was used to pitch the series.
Kaitlin Olson's audition scene for the series was her reading Dennis' part from the opening scene of "Charlie Has Cancer." Olson later said she didn't realize it wasn't the actual dialog for her character and was disappointed that she didn't get to do the scene on the show.
Artemis is inspired by Coyote Ugly when auditioning to work at the bar to help Dee. Kaitlin Olson, who plays Dee, was in Coyote Ugly.
The first time Mac and Dennis' apartment is shown.
Charlie is seen reading a book in the café. In the later episodes it's a long running joke that Charlie has problems reading and writing.