The coffee machine in the diagnostic room next to House's office says "Good Coffee - Cheaper than Prozac!"
One of the first times that lupus presents as a possible diagnosis.
When Wilson says to House, "I wanted to make sure you don't start firing shots from the clock tower," he's referring to the Texas Clock Tower shooter, Charles Whitman, who shot people from a clock tower at the University of Texas in 1966.
About twenty-one minutes in, as House and his team discuss possible diagnoses, there's a bag of "Wawa" brand coffee behind House, although it's blotted out, probably due to brand copyrights. The medical establishment that serves as the setting of House MD is in Princeton, NJ, and Wawa's are popular convenience stores that are spread throughout the tri-state area (NJ, PA, DE) and also in Maryland.
The Porsche driven in the opening scene is a 996, the 5th generation of the iconic sports car. Among other design changes this model was the first water cooled engine and a redesigned front end with the notorious "fried egg" headlights which were not well received by many Porsche enthusiasts.