One of the drugs Frasier makes Daphne get for him is syducane, which is a play on words and reference to one of the show's writers Sy Dukane.
The voices of struggling couple Howard and Lois (Steve Lawrence and Eydie Gormé respectively) had been married in real life since 1957 and remained so until Gormé's death in 2013.
The dessert Gil (Edward Hibbert) recommends to caller Louis (Garry Trudeau), the schwarzwälderkirschtorte, is German Black Forest cake.