Although the guys are portrayed as being suburbanites-turned-bikers from Cincinnati, Ohio, none of the filming in the movie actually took place in Cincinnati.
In the early scene where Dudley loses control of his bike after parking, it is obvious from the distinctive road signs that they are filming in downtown Albuquerque.
Was #1 during its opening weekend in the U.S., earning $39.7 million.
The original script and logo line featured the notorious Hells Angels motorcycle gang, but it was later changed to the Del Fuegos after the famous club sued Disney.
When Jack (Ray Liotta) is confronting the Wild Hogs in the biker bar, the beer he is drinking is clearly Michelob Ultra, a low-carb, light beer.
When Peter Fonda's character Damien Blade tells the Wild Hogs to lose their watches, it's a subtle reference to Easy Rider (1969), which starred Fonda. In the beginning of that movie Fonda's character Wyatt throws his watch away for the upcoming road trip.
The army-green bike Jack (Ray Liotta) is riding has the Orange County Choppers logo, the custom bike building company made famous in "American Chopper: The Series" (2003).
During the credits at the end of the movie, a mock clip of "Extreme Makeover: Home Edition" (2003) plays, featuring Ty Pennington and the Del Fuegos. In it, the gang finally receives a home because they lived in a broken home, but "never really had a home".
The scene in the Del Fuegos bar when Woody was squinting was almost entirely improvised. The cast had done the scene a couple of times and would ad-lib occasionally. One time John Travolta just started squinting in a Clint Eastwood impression. The other characters' reactions were real. They were expecting John to say his lines but kept going with it.
The police officers in the town of Madrid state that they got their firearms training from Doom (1993) (VG), the video game. The sheriff later says, "This is like the 12th level of 'Doom'."