Resident Evil 5 takes place in 2009, roughly ten years after the events of the original Resident Evil, and six years after the fall of Umbrella. Chris Redfield, former S.T.A.R.S member and survivor of the Spencer Estate incident, is now a founding member and agent for the Bioterrorism Security Assessment Alliance who's job is to investigate and prevent biological outbreaks like the T-Virus outbreak that destroyed Raccoon City. Chris is deployed to Kijuju, Africa, to join Sheva Alomar in the apprehension of Ricardo Irving, who is attempting to smuggle and sell bio-organic weapons on the black market in Africa.
The two attempt to rendezvous with the BSAA's Alpha Team, who were attempting to intercept Ricardo Irving. However, the situation quickly escalates as their local contact (Reynard Fisher) is executed and the pair are forced to fight literal crowds of Majini.