The pilot was created by three Hollywood actors. The first pilot episode only cost $200 to make and was shot on digital camera. It was then shopped around to different networks and was picked up by FX. They then moved the setting of the show from LA to Philadelphia and re-shot the pilot.
Each episode ends with the RCH production logo, with the actors in hoodies with a sound clip played backwards: * In Season 1, when this is played forward it says "You are stupid for playing this forward." At the end of the first-season finale "Charlie Gets Molested", the message had an echo. * In Season 2, when this is played forward it says "Is it brown? Is it brown? Is it brown? Good work. Is it brown? Is it brown? Is it brown? Good work." * In Season 3, when this is played forward, it says "Make it brown, Make it brown, make it brown, Make it brown!" in a cappella for the first three "Make it brown"s by each actor, and then in unison for the fourth and final "Make it brown".
Danny DeVito was only available for 20 days of shooting for all of season two.
The original title for "Hundred Dollar Baby" was scheduled to be "Sweet Dee Takes Steroids", but was changed as a play on words to the movie, Million Dollar Baby (2004).
Charlie's "war hero" costume in the episode "Charlie Gets Crippled" is based on famed Vietnam war protester and writer Ron Kovic.
Was almost canceled after its first season but renewed at the last minute when FX executives decided to give it room to grow. Ironically, it is now one of the highest rated and most popular shows on the channel.