Rufus, an old friend of Bobby's calls, panicked about demons attacking a town in Colorado. Sam and Dean arrive to help, but soon discover things aren't exactly as they seem.
Sam decides to stop hunting but has a hard time after he receives a surprise visit. Dean and Castiel try to find the Archangel Raphael in their bid to stop the Apocalypse.
Dean refuses Sam's efforts to help him battle the Devil, and then wakes up to find himself five years in the future, in a wasteland where Lucifer has begun his endgame by unleashing a virus that transforms humans into zombies.
Sam and Dean head to a small town where people are murdered by famous dead icons. However the brothers come to a dead end when two teenagers reveal they saw Paris Hilton kidnap their friend.
Dean and Sam investigate a series of murders that resemble fairy tales and urban legends; the brothers track down an 11-year-old boy that Castiel deems a serious threat.
Dean and Sam learn that a witch is running a poker game where the currency is life years versus money; Dean tries to intervene when Bobby starts losing the game.
Dean and Sam are at a Supernatural convention where they meet lots of fans of the Supernatural Books. After a while they get the impression that something is not right at the location of the convention.
The renegade angel Anna escapes from her prison in heaven. She travels back in time to kill Sam and Dean's parents so that Sam is never born, and cannot be the vessel for Lucifer. Castiel sends Sam and Dean back to stop Anna.
Dean and Sam are killed by the hunters Walt and Roy. They awake in heaven and Castiel contacts Dean and asks him to seek out the angel Joshua. Meanwhile Zachariah is chasing them in Heaven to force Dean to be Michael's vessel.
Crowley offers to help the brothers hunt down Pestilence and reclaim his ring, while Dean gets a lesson in trust when Sam's history with the Four Horsemen's demon `Stable Boy' is revealed.