Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.
When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel's hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.
Sam and Dean investigate a case that leads them to a devout religious family living off the grid. They realize the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.
After learning that the soul of Adolf Hitler has been trapped in a 1930's gold pocket watch, Dean and Sam must act quickly to prevent a group of Nazi necromancers from resurrecting the Führer.
When hunters gather together to celebrate the life and tragic death of one of their own, Sam, Dean and Mary must take action when a demon starts picking off hunters one by one.
Lucifer realizes that as Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, he arranges a VIP concert in order to kill them. Sam, Dean and Castiel enter the underbelly of the music industry to stop him.
Sam and Dean must find a way to escape from a government-run detention facility; in an effort to find her sons, Mary and Castiel seek assistance from a surprising source.
Mary asks Sam, Dean and Castiel for help on a case she's working, but neglects to mention the British Men of Letters are involved. When Mary is double crossed, everything is revealed.
Sam and Dean investigate an attack by an invisible hellhound at a campsite. Meanwhile, two of Crowley's own personal demons uncover what he has been hiding. Elsewhere, Castiel gets a lead on Kelly Kline.
Dean and Sam let Mick Davies tag along on a case as they search for a werewolf and they run into Claire Novak, the reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.
Sam comes up with a way to stop Lucifer's baby, but Castiel has something else in mind for Kelly. Dean is furious when he finds out someone stole the Colt.
Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni is back in the states and she and Mary face off.
Sam and Dean only have each other to rely on when they're caught in a dangerous situation; the fight between the American hunters and the British hunters comes to a head.