Kirstie asks John Travolta why they didn't hook up and Travolta mumbles, "...well, you married that other guy, and.." "That other guy" is her ex-husband, actor Parker Stevenson.
"Fat Actress" is about the life of overweight Hollywood actress Kirstie Alley. It is loosely based on her actual life, but is primarily--satirically--fictional.
Several Hollywood celebrities appeared in the series as themselves.
Bryan Callen and Michael McDonald are both from "MADtv."
Kirstie Alley and Rhea Perlman previously worked together on the last six years of Cheers.