Malcolm McDowell ruined a great number of takes by invoking hysterical laughter in the other actors.
William Forsythe actually injured his leg prior to shooting, which is why his leg is in a cast in the film. In the script, the character only had an arm brace, but Forsythe's leg injury was also worked into the film.
The inclusion of the plotline about Michael Myers' early days at the mental asylum under the care of Sam Loomis is a nod to a plotline added in by John Carpenter for the television viewing of the original Halloween (1978). As told by Carpenter, when the original film was first sold to television, they demanded added scenes to replace the edited portions of the murder scenes. So Carpenter recalled Donald Pleasence, the original Sam Loomis to film scenes of him at the hospital taking care of Michael.
(at around 54 mins) The film was mostly shot in South Pasadena, California, the same area where John Carpenter's original film was filmed. When Laurie notices Michael watching her and the girls at the library, Michael is actually standing in front of Laurie's house from the original film. Also, Laurie's house is located on the same street that Jamie Lee Curtis, Nancy Kyes and P.J. Soles walk down in the original film when Michael Myers drives past them in the station wagon.
The movie's production was delayed due to the death of Moustapha Akkad, the producer of all eight previous movies. Akkad died of severe injuries as a result from the terrorist attacks at Jordan in 2005.