John Corbett had to turn down the role of Thomas Miller because of his contractual obligations to Lucky (2003). He agreed to be a guest star on the show, portraying Thomas Miller's best friend, but the series was canceled before that could happen.
Nia Vardalos' character changed from Toula, which was her name in My Big Fat Greek Wedding (2002), to Nia.
Thomas Miller was named Ian Miller in the original movie.