In the first episode, Gary says that creating Lisa is possible because he saw it in a John Hughes movie once. The movie of course is Weird Science (1985), which spun off the series.
During the making of the series, Vanessa Angel (Lisa) was introduced to her husband Rick Otto by Lee Tergesen (Chett Donnelly).
Kelly LeBrock, who played Lisa in the 1985 movie, was asked to play Lisa again in this TV adaption, but turned the role down.
The show is credited from 1994 to 1998; however, all the episodes finished filming in 1997 (with the show canceled before airing the final six episodes). The final six were shown in 1998 during syndication reruns.