As there was not a set of female quintuplets that existed at the time of filming, two sets of triplets had to be cast: Grace (Cecile), Bonnie (Cecile), and Erin (Annette) Morris-Vanasse; Samantha (Emilie), Brooke (Yvonne), and Emily (Marie) Gilliland.
The newborn quintuplets were not actual babies, but animatronics built especially for the movie.
The character of movie actor Kurt Dietrich (Reg Dreger) is clearly modeled on Jean Hersholt who starred with the real Dionne Quintuplets in The Country Doctor (1936).