The role of Mother Superior was originated on Broadway by Geraldine Page. Page was passed over for the film version, in favor of Anne Bancroft. Bancroft was nominated for an Academy Award, but lost, ironically, to Page.
The roles given to Jane Fonda, Anne Bancroft and Meg Tilly were portrayed on Broadway by Elizabeth Ashley, Geraldine Page and Amanda Plummer.
Jane Fonda had to start chain-smoking for her part even though she hates to smoke.
Anne Pitoniak who portrays Jane Fonda's mother in Agnes of God, was the original Mother Miriam Ruth when the play was first produced at Actors Theatre of Louisville.
Agnes of God opened at the Music Box Theater on March 30, 1982 and ran for 599 performances.