The title of the pilot episode is a reference to the law signed by then-governor Ronald Reagan authorizing the creation of emergency medical services in California.
One of the three squads (the 1972 Dodge Ram D250 rescue vehicles driven by the paramedics) has been fully restored and is now located at the Los Angeles Fire Museum in SouthGate, California.
The fire station seen in the opening credits is actually Station 127 and is located in Carson, California at 2049 223rd Street (off Wilmington, and across from the Arco Refinery). Station 127 was renamed "R.A. Cinader Memorial Fire Station 127" after the death of "Emergency!" producer R. A. Cinader.
The fire station where John Gage was stationed at the beginning (Station 10) is L.A. County Fire Station 8, located at 7643 Santa Monica Blvd., in West Hollywood.
Roy DeSoto had a wife named JoAnn that was often mentioned but rarely seen. However, she is seen during a party scene in this pilot.