- Revealing mistakes: At the crash site of the Phantom F-4, the tail section of the crashed aircraft is that of an F-100.
- Factual errors: When the scientists in Piedmont check the dead driver of the satellite recovery van, his eyes are glistening wet. He had been dead for many hours, so they should have been dried out.
- Audio/visual unsynchronized: After the two scientists in hazard suits are dropped-off in Piedmont, there is a shot of the helicopter hovering overhead, yet the sound effect is that of a helicopter flying away. Moments later the helicopter does fly away slowly.
- Audio/visual unsynchronized: A close-up of the crying baby found in the town by the recon scientists shows the face of a baby that is obviously not crying as the soundtrack portrays.
- Revealing mistakes: The lips of the dead man in the barber's chair in Piedmont can be seen moving in the close shot.
- Revealing mistakes: When the scientist moves to close the dead doctor's eyes in Piedmont, the man's eyes close before the scientist closes them.
- Continuity: When the lead scientist is handling the satellite in the clean room with robot arms. The clocks in the background show vastly different times between shots although only a short time (seconds) has passed.
- Errors in geography: According to the map shown after the Situation Room scene, Wildfire was located in southern Clark County, Nevada, 46 miles from downtown Las Vegas, 34 miles from The Hoover Dam, and only five miles from Searchlight, Nevada; notably closer than 112 miles from any "...inhabited area..." as stated in the dialogue.
- Crew or equipment visible: When they first subject the lab animals to the virus, on the right hand side of the screen in the reflection of the metal walls you can see the crew rushing towards the monkey cage to revive him right before they cut back to the shot of the scientists.
- Errors made by characters (possibly deliberate errors by the filmmakers): In the scene when the two scientists are first exploring the town, we see a shot of a priest lying dead on the steps of a church, eyes wide open. Right before the scene cuts, the supposedly dead priest stops his dead-eyed stare and looks to the right, obviously moving both eyes.
- Factual errors: The screen showing the distribution of elements in the samples goes by atomic number, but skips over neon (10) for some reason. (It can't be because of lack of neon; other elements are indicated with a 0 or -.)
- Revealing mistakes: When Dutton, Stone and Hall walk towards the electrostatic decontaminator, they are shown full-body from the rear to be nude entering the chamber. The next scene, tastefully blurred and solarized, still shows Dutton and Stone wearing athletic supporters, and Hall wearing bikini underwear.
- Continuity: When the scientists get to the doctor's office in Piedmont, they leave the driver's side door of the van open, almost farther than a standard van door is allowed to open. When they return, it is open only that standard amount.
- Revealing mistakes: When Dr. Hall is being scanned, you can see in the reflection on the screen that he is wearing an athletic supporter.
- Continuity: The oscilloscope in Scoop Mission Control shows the voices from the recovery team, but not the beeping of the tracker. This can be seen clearly after the team dies and the trace flat lines.
- Factual errors: When Hall first uses the Medcom program on the computer in Level 5, the word "analysis" is misspelled as "ANALYS".
>>> WARNING: Here Be Spoilers <<<
Goofs below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- Plot holes: SPOILER: The story shows the only Destruct Substations located in passageways. Considering that individual labs seal off if they become contaminated, every single room should have had a Destruct Substation. If Dr. Hall had been stuck in the lab with Dr. Dutton, the story would have ended on a tragic note.
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