Myrna Loy had originally been scheduled to make "The Road to Rome" with Clark Gable, but its anti-war message would have made it a difficult movie to market with World War II going on in Europe. The film was shelved and Loy moved on to make this film instead. She did not mind the change, as she was a great friend of William Powell and loved working with him.
This marked the fifth time that William Powell and Myrna Loy had acted together in a film directed by W.S. Van Dyke.
When "Larry" is brought home after supposedly fainting and is lying on the bed, Doc Ryan shoos everybody out and says "All right, little Eva, you can ease up on the dying now". "Little Eva" was a character from the famous novel "Uncle Tom's Cabin"; in the play version she has a long dying scene.