William Boyd and Clark Gable, during the making of the film (11 October 1930), narrowly escaped serious injury from falling rock after two tons of explosives went off with considerably more force than planned in Dinosaur Canyon, some 70 miles northwest of Flagstaff, Arizona. While Boyd and Gable were 200 feet from the blast, rocks and boulders rained down between where they were standing. Not so lucky were a number of technicians, some 15 of whom were taken to hospitals in Flagstaff and Tuba City, and director Howard Higgin, who suffered a broken ankle and various cuts. The female lead, Helen Twelvetrees, had already returned to Los Angeles, as most of the principal photography was completed. Dynamite and black powder had been placed in the face of a 400-foot cliff and in an old mine tunnel, the explosion being expected to crumble the cliff. Unexpected presence of hard rock lent the blast violence that had not been anticipated, and showered rock and stone over an area of nearly half a mile.
The Painted Desert was one of the last features to be produced by Pathé in 1930 before being taken over by RKO, and one of the first to be released by the emerging RKO-Pathé Distributing Corporation. After its initial release it was put back on the shelf, supposedly never to be seen again. During this time four key action sequences were removed to be used as stock footage in later RKO films, among them the 1938 re-make also titled The Painted Desert. In 1955 the RKO library was sold to C&C Television Corporation for TV syndication, primarily on CBS affiliated stations, and both versions of The Painted Desert were in the package. 35MM source material for these 16mm television prints was missing all of the deleted footage, so that what remained, and all that viewers have been able to see for the last sixty-five years, was a lot of talk, and practically no action. The sequences which are missing are most of the cattle stampede at the beginning of the film, a wagon hi-jacking and subsequent stampede into the canyon mid-way into the film, an attempted, but unsuccessful wagon hi-jacking soon afterwards, and the big mine explosion and resultant landslide that destroys the mining camp further on. (Two very impressive shots from this last sequence can be found in Republic's Red River Valley (1936).) Frustratingly, the results of these events are shown, and much talked about, but the events themselves are nowhere to be seen. The version shown on Turner Classic Movies, though of superior visual quality, having been derived from the surviving original 35MM material, is still missing these key sequences, though no mention is made of it on the air.
The first sound film in which Clark Gable appeared, although his voice was heard in Du Barry, Woman of Passion (1930).
Tragedy struck the production shortly after filming began when the fourteen-month-old baby playing the role of the infant Bill Holbrook died while on location. The cause of death was not released. The infant's name was Thais Baer, and she was from Glendale, Arizona.
Clark Gable couldn't ride a horse when he was cast this film. Producer E.B. Derr asked Gable if he could ride a horse and he said he could. Before shooting began, he learned to ride from Art Wilson, a former Montana cowboy, who gave lessons at the Griffith Park Riding Academy in Los Angeles.